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Evidence is increasing that every addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in establishing food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err to the side of caution and allow the FDA do its job and demand some study be done so your public recognizes the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on their own medications.

Researchers found out that participants investing in this drug for the year, dropped excess weight within one month and have kept the weight off through the 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which may make them far better and safer.

Combo-pilling will be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that by right now there are not any long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure and heartbeat, and really should not be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.


New UCLA study on smokers with mental, drug, and alcohol problems

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